Endocrine Abstracts

Little is known about the negative regulation of angiogenesis in the ovary. Recent evidence has revealed that estradiol 17β and its metabolites may play an important role in this fine tuning1. In a previous work2, we set up an assay to quantify 2-hydroxyestradiol (2-OHE) and 4-hydroxyestradiol (4-OHE) in follicular fuids. In order to get an insight on the angiogenic effect of 4-OHE and 2-OHE, the objective of this research was to study their possible...